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  • Writer's pictureNancy Mullan, MD

A Critical Gene For Your Health

Updated: Jan 23, 2020

Are you sick and tired of feeling sick and tired?

Have you been to 60 doctors and still have no answers?

Are you feeling hopeless about regaining your health?

If you don’t know about your MTHFR C677T gene status, you can be stumbling around in the dark as you try to resolve symptoms. You can be using the wrong supplementation for your genetic type. Knowledge about your MTHFR C677T gene can clarify the mistakes, sort out the confusion, and move you in the right direction. You need to supplement very carefully for this mutation, taking into account not only this gene, but also a number of other genes that impact the pathway in which MTHFR functions.

A mutation at MTHFR C677T reduces the number of methyl groups you can make. A methyl group is a small but mighty molecule. Other important small molecules are O2 (oxygen), H20 (water), and NO (Nitric Oxide), that is important for blood vessel diameter. These small molecules are critical to life.

Below is a depiction of a methyl group:

Methyl groups are central to the regulation of gene activity. They silence genes. At any point 80% of your genes should not be expressing. If you do not have adequate methyl groups, you will have aberrant gene expression and the problems that come with it.

Without enough methyl groups, you don’t form molecules that make DNA and RNA. Without these, making new cells is impaired. You age more rapidly. Wound healing is slow. You do not learn new tasks readily or have the ability to adapt to the changes in your environment easily. Your energy may sink to new lows. You may develop high homocysteine and the vascular inflammation and heart disease that come with this condition.

Beyond that, your methyl group producing pathways are intimately connected to your detox pathway.  An MTHFR C677T mutation will reduce your ability to detox. There are other important biochemical pathways that connect to your methyl group producing ones, like pathways for neurotransmitter production, urinary excretion and folate metabolism. So you really need to address the MTHFR mutation if you have one.

If you are using a mainstream doctor, odds are they won’t know about MTHFR at all. New ideas can take a while to get into the mainstream. If you are using a Functional Medicine practitioner, they may know about it, but they won’t know the intricacies of the biochemistry needed to get the important interconnected pathways to function smoothly. They will give you methyl folate and/or methyl B12 that may help, or it may make you feel awful.

I am one of very few methylation genetics experts in the US.

I work with more people who have MTHFR C677T mutations than any other doctor. It is my area of specialization. I work with Dr. Amy Yasko who ‘wrote the book’ on this. Her protocol looks at the intimate biochemistry in the connected group of pathways surrounding the MTHFR C677T mutation that impact on its function.

I have a free, downloadable ebook that you can opt in for at that gives you further detail about these issues. Click here to get your free ebook.

Why stumble around in the dark? You can go for weeks trying a solution that is flat out wrong for you, then try another one that doesn’t work any better. You end up feeling lost and desperate and like there is no hope. I help people just like you all the time. Try an Exploratory Conversation with me. In this 30 minute conversation, I will listen to your symptoms, look at the lab tests you email me, tell you what I think, and leave you feeling enlightened and relieved. What I tell you will make sense, that there is a path forward, that you have found a clinician who ‘gets it.’  My fee is $129 for this conversation. It is quick and easy and does not involve becoming a patient. I can clarify your confusion and pull you out of the muddle.

Email me at and ask for this time with me.

I look forward to being able to help, Dr. Nancy Mullan

What people like you are saying about Dr. Mullan’s work:

I shudder at the thought of what my family would be like without Dr. Mullan. Thankfully, with her help, we have stopped my husband's chronic 30 year battle with kidney stones. He is no longer forming them and is stone free. My thyroid is now working normally, my body temperature is almost normal and my hair has grown back. My oldest daughter's Autism is in the process of being reversed and her hair pulling has stopped. The greatest blessing from our good health is the birth of my second daughter Ava, now one-year-old. At 50 years old I carried her to term. One of my doctors commented to me saying “ you are carrying this baby like a 22-year-old.” Yes, I am because of Dr. Mullan and working on my methylation pathway. One by one she is knocking off symptoms and bringing us back to health. The future is bright! Thank you, Dr. Mullan, for the work you do.


Wow. I feel great. Thank you for your help. It's amazing really. Like a light turned on. Curious to see what the next tests show. To ride this peak indefinitely is my goal. Ha. I have energy again. Yay!

Really grateful,


I am so relieved. My daughter is doing SO WELL since we started with you! We have been to so many doctors and tried so many things.Now I can start working on my own program with you....


So excellent! I literally learn something every single time and I get clarification on things that have been lingering in my mind… VB

You are giving people a huge gift by empowering them… It’s about helping the patient become their own healer by taking them to a higher level of consciousness… AL

Thank you so much, Dr. Mullan. Thank you so, so much for everything you do. MS

Wow! I have to tell you, this was such an uplifting session. It’s so nice to hear good news, especially about a child. Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me. So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!! TR

Fantastic, caring, smart, savvy doc. I worked with Dr. Mullan for a couple of years to help MTHFR mutations and their associating expressions! To say the least! She's brilliant. At that time she had weekly calls for her patients - free - where we could ask questions and she would reply. What doctors do this? She does. She's also an animal lover and is right on about the way she practices medicine. I highly recommend her. In good health!


"Dr. Nancy Mullan is a beautiful person. She is an expert in her field and has helped our family so much. I am very grateful to her. She came highly recommended and I know why. I would recommend her and her website for information re: healing from a genetic point of view. Thank you, Dr. Mullan, for everything.”


"Dr.Mullan has helped me with issues that I have struggled with for years. She is knowledgable and practical. I would recommend her to others.”


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