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  • Writer's pictureNancy Mullan, MD

The Ups and Downs of the MTHFR Gene Mutation

Updated: Jan 23, 2020

First the bad news...

An MTHFR mutation reduces the number of methyl groups that you can make. Methyl groups are the simple biochemical molecule with one carbon atom and three hydrogen atoms pictured below. Your body uses them in many biochemical reactions that regulate the activity of the cardiovascular, neurological, reproductive and detoxification systems.

If you underproduce methyl groups, you can have impaired DNA formation, slow wound healing, lower immunity, low neurotransmitter production, poor detoxification, slow histamine breakdown and the allergic attacks that follow. It can impact your eye function, fat metabolism, cellular energy levels, liver function and estrogen metabolism. It can mess you up royally.

Your body just won’t work right because a very central biochemical regulator is in short supply. Methyl groups silence genes. At any given time 80% of your genes should not be functioning. If you do not have enough methyl groups to do that, genes that should be silent will be expressing and those that should be expressing may not do so. The result is chaotic biochemistry, your feeling awful and getting sick.

Now the good news...

You can supplement methyl groups to bypass this mutation. You have to do it carefully. And you may have to support other areas of your biochemistry to get your body to function well. But it can be done.

5 Methyl folate is the molecule that is missing. Standard medical practice is to pound your body with Deplin, high dose 5 methyl folate. That may be OK for some people, but it may not work so well for you. There are subtleties to methyl group formation. You also need to know the status of the biochemical pathway in which methyl group formation happens.

Many doctors will just tell you they don’t know much about the MTHFR mutation. This is honest, but it isn’t optimal if you have one. Your body will not respond to pharmaceuticals or supplements normally. Your doctor may get confused and give you the wrong thing. Or he may give you the right thing in the wrong dose. There are a lot of ways your treatment can go wrong and your well functioning can be delayed.

If you have an MTHFR C677T gene mutation, you won’t be able to ignore it. You have to take how it shifts your biochemistry into account and work through it. You have to find out what you need to do for your particular genetics from a doctor who knows how this works. I am an MTHFR specialist with over ten years experience of working with this gene and the biochemical pathways surrounding it. I do not know another doctor with this kind of experience. I work with Dr. Amy Yasko who is the world expert in this area.

I have a free, downloadable ebook that you can opt in for at that gives you further detail about these issues. Click here to get your free ebook.

Why stumble around in the dark?

You can go for weeks trying a solution that is flat out wrong for you, and then try another one that doesn’t work any better. You end up feeling lost and desperate. You lose hope. I help people just like you all of the time.

Have an Exploratory Conversation with me.

In this 30 minute conversation with me, I will listen to the problems you have been having, look at the lab tests you email me, tell you what I think, and leave you feeling relieved. What I tell you will make sense, that there is a path forward, that you have a doctor who ‘gets it.’ My fee is $129 for this conversation. It is quick and easy and does not involve becoming a patient. I can clarify your confusion and pull you out of the muddle. Contact me at and ask for this time with me.

I look forward to being able to help, Dr. Mullan

What people like you are saying about Dr. Mullan’s work:

I shudder at the thought of what my family would be like without Dr. Mullan. Thankfully, with her help, we have stopped my husband's chronic 30 year battle with kidney stones. He is no longer forming them and is stone free. My thyroid is now working normally, my body temperature is almost normal and my hair has grown back. My oldest daughter's Autism is in the process of being reversed and her hair pulling has stopped. The greatest blessing from our good health is the birth of my second daughter Ava, now one-year-old. At 50 years old I carried her to term. One of my doctors commented to me saying “ you are carrying this baby like a 22-year-old.” Yes, I am because of Dr. Mullan and working on my methylation pathway. One by one she is knocking off symptoms and bringing us back to health. The future is bright! Thank you, Dr. Mullan, for the work you do.


Wow. I feel great. Thank you for your help. It's amazing really. Like a light turned on. Curious to see what the next tests show. To ride this peak indefinitely is my goal. Ha. I have energy again. Yay!

Really grateful,


I am so relieved. My daughter is doing SO WELL since we started with you! We have been to so many doctors and tried so many things.Now I can start working on my own program with you....


So excellent! I literally learn something every single time and I get clarification on things that have been lingering in my mind… VB

You are giving people a huge gift by empowering them… It’s about helping the patient become their own healer by taking them to a higher level of consciousness… AL

Thank you so much, Dr. Mullan. Thank you so, so much for everything you do. MS

Wow! I have to tell you, this was such an uplifting session. It’s so nice to hear good news, especially about a child. Anxiety, OCD and a host of other mental/psychiatric symptoms have been a huge hurdle for me. So to hear this story of all those awful symptoms totally going away is such a bright light for me!!!! TR

Fantastic, caring, smart, savvy doc. I worked with Dr. Mullan for a couple of years to help MTHFR mutations and their associating expressions! To say the least! She's brilliant. At that time she had weekly calls for her patients - free - where we could ask questions and she would reply. What doctors do this? She does. She's also an animal lover and is right on about the way she practices medicine. I highly recommend her. In good health!


"Dr. Nancy Mullan is a beautiful person. She is an expert in her field and has helped our family so much. I am very grateful to her. She came highly recommended and I know why. I would recommend her and her website for information re: healing from a genetic point of view. Thank you, Dr. Mullan, for everything.”


"Dr.Mullan has helped me with issues that I have struggled with for years. She is knowledgable and practical. I would recommend her to others.”


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